Most of Ephesians 4 and all of Ephesians 5 address what it means to live as children of light, or more conventionally, what it means to live holy lives. Paul gives many commands and instructions, but ultimately men and women are made holy by the Spirit who is called Holy. Therefore Paul’s command in Eph. 5:18—“Be filled with the Holy Spirit”—is the culmination of these chapters, both rhetorically and theologically. The passive imperative—“be filled”—is followed by four subordinate participial clauses: (1) speaking to one another in songs, hymns, and spiritual songs; (2) singing and making music in your hearts; (3) giving thanks to the Lord; (4) submitting to one another. These participles are grammatically dependent upon the verb, and they give substance and content to the command to be filled with the Spirit. And remarkably, two of the four clauses—three of the five participles—have to do with making music.
—Stephen R. Guthrie, “Singing, in the Body and in the Spirit,” Journal of the Evangelical Theological Society 46/4 (December 2003), 639